Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study

Exclusion Criteria

• •Presence or history of erectile dysfunction or other sexual or ejaculatory disorders such as retrograde ejaculation or acquired premature ejaculation.
• •History of acute or chronic prostatitis.
• •Any debilitating medical condition including hepatic failure, renal failure, or uncontrolled diabetes mellitus.
• •Previous pelvic or spinal surgery.
• •Prior chemotherapy or radiotherapy.
• •Use of antipsychotic or neuroactive medications that may affect ejaculation.
• •History of substance abuse or current drug dependence.
• •Presence of penile prosthesis, penile deformity, or anatomic abnormalities of the glans or shaft.
• •Known hypersensitivity or allergy to botulinum toxin or hyaluronic acid preparations.
• •Any condition that, in the investigator's opinion, may interfere with the safety or evaluation of the study treatment.