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Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial | Clinical Trials | Clareo Health

RECRUITINGNA

Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial

NCT06570135•Xijing Hospital

View on ClinicalTrials.gov

Summary

This is a controlled study of patients with and without primary premature ejaculation. It is based on near-infrared spectroscopy (NIRS) functional brain imaging to detect and compare changes in brain activity in resting and task states (Simulated Sex) between the two groups of patients.

Eligibility

Age

18 - 45 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•patients' age varied from 18 to 45 years；
•patients met the 2014 International Society for Sexual Medicine (ISSM) definition criteria for PPE；
•patients had a stable, heterosexual relationship with a single sexually active female partner for at least 6 months and with at least two sexual intercourses a week and kept stable during the study period;
•Patients with premature ejaculation lasting longer than 6 months；
•patients were identified if their scores were higher than 9 on the Chinese version of Premature Ejaculation Diagnostic Tool (PEDT);
•patients had no history of any previous therapies for PE or had recently stopped the therapies for at least 3 months
•patients had fully informed consent, signed informed consent form
•Men between the ages of 18-45 years were included according to an age difference of \<3 years between each patient and the primary premature ejaculation group, and if more than one volunteer was eligible at the same time, the one with the closest age was selected；
•Patient does not meet the 2014 International Society for Sexual Medicine (ISSM) criteria for defining premature ejaculation；
•patients had a stable, heterosexual relationship with a single sexually active female partner for at least 6 months and with at least two sexual intercourses a week and kept stable during the study period;
+1 more criteria

Exclusion Criteria

•patients were diagnosed with secondary PE, variable PE, and subjective PE;
•patients were using medications for endocrinological, metabolic, chronic systemic, or psychiatric diseases;
•patients were abusing alcohol or illegal drugs；
•patients were diagnosed with erectile dysfunction (ED) if their scores were \<21 on the abridged five-item International Index of Erectile Function (IIEF-5)
•patients were diagnosed with sexual hormone abnormalities, hyperthyroidism, hypothyroidism, Peyronie's disease, prostatitis, urethritis, or urinary tract infection;
•patients with head injuries that prevent them from completing near-infrared light brain function imaging
•Patients with severe schizophrenia, anxiety, depression or other neurological symptoms or poor compliance

Locations (2)

Air Force Military Medical University

Xi'an, Shaanxi, China

Air Force Military Medical University

Xi'an, Shaanxi, China

Key Dates

Start Date

April 8, 2025

Primary Completion Date

December 30, 2025

Completion Date

December 30, 2025

Last Updated

April 17, 2025

Enrollment

ESTIMATED participants

Conditions

Premature Ejaculation

Interventions

Detecting Brain Activity with Functional Near Infrared Spectroscopy

DIAGNOSTIC_TEST

Contacts

Weijun Qin, M.D

CONTACT

13572501300 qinwj@fmmu.edu.cn

Study to Evaluate the Potential Effects of KH-001 on Intravaginal Ejaculatory Latency Time (IELT), Patient-Reported Outcomes, and Safety in Men With Lifelong Premature Ejaculation (LPE)

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Premature Ejaculation

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NOT_YET_RECRUITINGNA

Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study

NCT07236632

Premature Ejaculation

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COMPLETED

THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMES

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: April 17, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Brain Activity During Sexual Behavior in Patients With Primary Premature Ejaculation a Clinical Trial

Inclusion Criteria

Exclusion Criteria

Study to Evaluate the Potential Effects of KH-001 on Intravaginal Ejaculatory Latency Time (IELT), Patient-Reported Outcomes, and Safety in Men With Lifelong Premature Ejaculation (LPE)

Hyaluronic Acid vs Botulinum Toxin Injection in Treatment of Lifelong Drug-Resistant Premature Ejaculation: Randomized Study

THE IMPACT OF VITAMIN B12 TREATMENT ON EJACULATORY FUNCTIONS IN MEN: SYMPTOMATIC RELIEF AND IMPROVED OUTCOMES

Primary Premature Ejaculation Genetics

Clinical Study to Reduce Premature Ejaculation in Healthy Adult Men

The Effect of Behavioral Therapy Given to Men and Their Partners'