RECRUITINGPHASE3

Methadone in TKA for Post-op Pain and Opioid Reduction

Reduction of Post-op Pain and Opioid Consumption With the Addition of Methadone in Total Knee Arthroplasty: a Double-blind Randomized Control Trial

NCT07226076•Medical University of South Carolina

View on ClinicalTrials.gov

Summary

This randomized, double-blind controlled trial investigates whether intraoperative IV methadone (0.15 mg/kg based on ideal body weight) reduces acute postoperative pain and opioid consumption in patients undergoing elective total knee arthroplasty under spinal anesthesia with mepivacaine.

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Inclusion
•Ages 18-75 years of age
•Undergoing elective primary total knee arthroplasty with mepivacaine in the spinal anesthesia
•Exclusion
•Allergy to methadone or mepivacaine
•Severe liver disease defined as Child's Pugh Class C
•End stage renal disease requiring dialysis
•Known diagnosis of prolonged QT syndrome
•Currently pregnant
•Unable to provide written, informed consent
+1 more criteria

Locations (1)

Medical University of South Carolina

Charleston, South Carolina, United States

Key Dates

Start Date

January 8, 2026

Primary Completion Date

December 28, 2026

Completion Date

January 15, 2027

Last Updated

February 4, 2026

Enrollment

162

ESTIMATED participants

Conditions

Post Operative Pain

Interventions

Methadone Hydrochloride

DRUG

Contacts

Haley Nitchie, MHA

CONTACT

843-792-1869 nitchie@musc.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 4, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

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RECRUITINGPHASE4