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Randomized Controlled Trial of Different Antibiotic Duration Prior to Prostate Enucleation Surgery

Randomized Controlled Trial of 3 vs 7 Days for Perioperative Antibiotic Prophylaxis for Patients With an Indwelling Catheter Prior to Holmium Laser Enucleation of the Prostate

NCT07209150•Ohio State University

View on ClinicalTrials.gov

Summary

To compare the risk of infectious complications (UTI, pyelonephritis, sepsis, hospital admission, ED visits) for patients with an indwelling urinary catheter (urethral or suprapubic) or CIC receiving 3 or 7 days of peri-operative antibiotic prophylaxis at time of Holmium Laser Enucleation of the Prostate

Eligibility

Age

18 - No limit years

Sex

MALE

Healthy Volunteers

Inclusion Criteria

•1\. Candidate for HoLEP surgery 2. Must be 18 years or older. 3. The patient must be able to understand and willing to provide informed consent as described in this study protocol.

Exclusion Criteria

•1\. Under the age of 18 2. Refuse to provide informed consent 3. Anticipated need for perineal urethrostomy 4. History of multi-drug resistant organism on urine culture that is not susceptible to any oral agents

Key Dates

Start Date

January 1, 2026

Primary Completion Date

December 30, 2027

Completion Date

July 15, 2028

Last Updated

October 6, 2025

Enrollment

250

ESTIMATED participants

Conditions

BPH With Urinary ObstructionAntibiotic Prophylaxis

Interventions

antibiotic prophylaxis

DRUG

Contacts

Matthew Lee, MD

CONTACT

614-293-8155 matthew.lee@osumc.edu

STI Prophylaxis and Emergence of Antimicrobial Resistance

NCT06778083

Sexually Transmitted Infection (STI) PreventionAntibiotic Prophylaxis+3 more

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RECRUITINGPHASE4

Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA

NCT05519072

Antibiotic Prophylaxis

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: October 6, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Randomized Controlled Trial of Different Antibiotic Duration Prior to Prostate Enucleation Surgery

Inclusion Criteria

Exclusion Criteria

STI Prophylaxis and Emergence of Antimicrobial Resistance

Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA

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