WATER III: Aquablation vs. Transurethral Laser Enucleation of Large Prostates (80 - 180mL) in Benign Prostatic Hyperplasia

Exclusion Criteria

• •1. Body mass index ≥ 42
• •2. Suspected or history of prostate cancer
• •3. Suspected or history of bladder cancer
• •4. Bladder stone
• •5. Indwelling catheter for more than 3 months before baseline
• •6. Active urinary tract infection
• •7. History of urethral stricture or bladder neck stenosis
• •8. Damage of the external urethral sphincter
• •9. Previous prostate surgery or history of lower urinary tract surgery (e.g. urinary diversion, artificial sphincter or penile prosthesis)
• •10. Use of anticoagulants (if medication cannot be stopped before and after procedure) or known coagulopathy (except ASS 100mg/d).
• •11. Contraindications for general and spinal anaesthesia
• •12. The investigator considers a pre-existing condition or the subject's life circumstances to be problematic for the conduct of the study and the completion of the follow-up investigations
• •13. Subject is unwilling to accept a blood transfusion if required
• •14. Subject is not able to give consent
• •15. Subject without legal capacity who is unable to understand the nature, scope, significance and consequences of this clinical trial
• •16. Simultaneously participation in another clinical trial in the field of urology
• •17. Known or persistent abuse of medication, drugs or alcohol