Drug-Drug Interaction of JMKX003142 With Amiodarone and Febuxostat in Healthy Subjects

Exclusion Criteria

• •1. Subjects having hypersensitivity to study drug or have a history of allergies to multiple drugs, foods, or other substances
• •2. History or presence of significant circulatory system, respiratory system, digestive system, blood system, urinary and reproductive system, endocrine and metabolic system, nervous system, mental system, muscular and skeletal system, skin system, lymphatic system, immune system, Otolaryngology or other related systems disease or disorder. as well as systemic or local acute or chronic infections.
• •3. Subjects with dysphagia, gastrointestinal diseases, or any conditions that may affect drug absorption; such as a history of hepatobiliary and pancreatic diseases, gastrointestinal diseases, gastrointestinal surgery (except appendectomy), or a history of chronic pancreatitis, idiopathic acute pancreatitis, or habitual diarrhea.
• •4. Vital signs during the screening period meet any of the following conditions: systolic blood pressure \>140 mmHg or \<90 mmHg; diastolic blood pressure \>90 mmHg or \<50 mmHg (Cohort 1: diastolic blood pressure \>90 mmHg or \<60 mmHg); pulse \>100 beats/min or \<50 beats/min (Cohort 1: pulse \>100 beats/min or \<60 beats/min); ear temperature \>37.5°C or \<35°C.
• •5. History of QTc interval prolongation or abnormal ECG results during screening, QTcF ≥ 450 ms for males or ≥ 470 ms for females, or QRS interval \> 120 ms.