Metabolic Impacts of Ren-Nu: A Dietary Program for Polycystic Kidney Disease

Exclusion Criteria

• •Intolerance or allergy to any of the ingredients in the provided medical food
• •* Severe or rare underlying health conditions may cause a safety risk when taking the medical food. Those underlying health conditions will be assessed by the enrolling physician and include but are not limited to:
• •* History of hyperkalemia
• •* Heart failure
• •* Liver cirrhosis
• •* Chronic kidney disease stage 4 or greater, or other renal condition that severely impairs bone mineral homeostasis.
• •* HIV infection
• •* Chronic drug or alcohol abuse
• •* Chronic malabsorption syndrome
• •* Malignancy (non-melanoma skin cancer exempted)
• •* Autoimmune disease
• •* Pregnant, planning to be pregnant, or nursing during the course of the study
• •* Chronic history of recurrent urinary tract infections (UTI) (≥ 3 UTIs per year)
• •* Diagnosis of aneurysm
• •* Indigestion due to hypochlorhydria (low stomach acid)
• •* Any other condition, that in the opinion of the enrolling physician, makes the subject an unsuitable candidate for the study.
• •* Current use of any of the following medications or supplements which could affect safety or compliance with this study:
• •* The medical food, KetoCitra®.
• •* Urine alkalizing agents such as sodium bicarbonate or potassium citrate
• •* Citrate treatments
• •* Immunosuppressive treatment
• •* Tolvaptan
• •* Potassium-sparing diuretics
• •* Somatostatin analogs
• •* Aluminum-containing supplements or medications such as aluminum antacids (e.g. Maalox) or aluminum-based phosphate binders.
• •* SGLT2 inhibitors
• •* Participation in another therapeutic intervention trial.
• •* Following a highly specialized or extreme diet that is incompatible with the interventional nutrition program (e.g. carnivore, very high protein diet for elite athletes, etc.)
• •* Food sensitivities or allergies that are incompatible with the interventional nutrition program.
• •* The subject is already adhering to a form of a ketogenic diet or related fasting regimen.
• •* Current or past history of disordered eating or feeding behaviors.
• •* History of gastric bypass.
• •* Active diagnosis of ulcerative colitis, Irritable Bowel Syndrome, Crohn's, or Gallbladder Disease.