TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.

Exclusion Criteria

• •1. Cardiac arrest due to trauma;
• •2. Suspected or confirmed hemorrhagic or ischemic stroke;
• •3. Pregnancy;
• •4. Cardiac arrest without witnessed collapse;
• •5. Admission body temperature \<30°C;
• •6. Persistent cardiogenic shock (defined as systolic blood pressure \<90 mmHg despite aggressive intervention during screening);
• •7. Any underlying disease with an expected survival of \<180 days;
• •8. Pre-existing severe neurological dysfunction before cardiac arrest (e.g., Cerebral Performance Category \[CPC\] 3-4);
• •9. Time from ROSC to randomization exceeding 4 hours;
• •10. Left ventricular ejection fraction (LVEF) \<35% after ROSC;
• •11. Known hypersensitivity to TNF-α antagonist components;
• •12. Known tuberculosis or other active infections;
• •13. Known poor prognosis (as determined by the investigator);
• •14. History of liver cirrhosis;
• •15. History of chronic heart failure with NYHA functional class III-IV.