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TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest. | Clinical Trials | Clareo Health

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TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.

TNF-a Antagonists Attenuate the Systemic Inflammatory Response in Post-cardiac Arrest Syndrome: a Multi Centre, Double-blind, Randomised Controlled Clinical Study

NCT07176754•Peking University Third Hospital

View on ClinicalTrials.gov

Summary

The investigators assessed the effect of TNF-α antagonism within 6 hours of return of spontaneous circulation on 30-day mortality in patients who remained comatose after cardiopulmonary resuscitation (CPR) following cardiac arrest . In addition, the investigators explored the role of this treatment in modulating the systemic inflammatory response and its potential impact on 90- and 180-day morbidity and mortality and neurological outcomes.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Patients aged ≥18 years;
•2. Patients with suspected cardiogenic cardiac arrest;
•3. Patients with comatose state after ROSC (Glasgow Coma Scale \[GCS\] score \<9);
•4. Patients with Return of spontaneous circulation (ROSC) sustained for \>20 minutes;

Exclusion Criteria

•1. Cardiac arrest due to trauma;
•2. Suspected or confirmed hemorrhagic or ischemic stroke;
•3. Pregnancy;
•4. Cardiac arrest without witnessed collapse;
•5. Admission body temperature \<30°C;
•6. Persistent cardiogenic shock (defined as systolic blood pressure \<90 mmHg despite aggressive intervention during screening);
•7. Any underlying disease with an expected survival of \<180 days;
•8. Pre-existing severe neurological dysfunction before cardiac arrest (e.g., Cerebral Performance Category \[CPC\] 3-4);
•9. Time from ROSC to randomization exceeding 4 hours;
•10. Left ventricular ejection fraction (LVEF) \<35% after ROSC;
+5 more criteria

Key Dates

Start Date

October 1, 2025

Primary Completion Date

July 31, 2028

Completion Date

October 31, 2028

Last Updated

September 16, 2025

Enrollment

208

ESTIMATED participants

Conditions

Cardiac Arrest (CA)Post Cardiac Arrest Syndrome

Interventions

Infliximab

DRUG

Sodium chloride injection USP, 0.9% (placebo)

DRUG

Contacts

Qingbian Ma

CONTACT

15611908229 maqingbian@126.com

MQingbian

CONTACT

Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.

NCT07438938

Cardiac Arrest (CA)Out-of-hospital Cardiac Arrest (OHCA)+1 more

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RECRUITINGNA

Evaluation of Mixed Reality Cardiopulmonary Resuscitation Training

NCT07363772

Cardiopulmonary Resuscitation (CPR)Basic Life Support Training Course+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 16, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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TNF-α Antagonists Mitigate Systemic Inflammatory Response After Cardiac Arrest.

Inclusion Criteria

Exclusion Criteria

Measurement of Airway Opening Index During Out-of-hospital Cardiac Arrest: The Lazarus AOI Trial.

Evaluation of Mixed Reality Cardiopulmonary Resuscitation Training

The Application of Positive End-Expiratory Pressure in Out-of-Hospital Cardiac Arrest: The Lazarus-PEEP Trial.

Mind-body Resilience Program for Cardiac Arrest Survivors and Their Caregivers: Recovering Together After Cardiac Arrest

Hypothermia Versus Normothermia After Extracorporeal Cardiopulmonary Resuscitation for Out-of-hospital Cardiac Arrest

Strategies for Defibrillation During Out-of-Hospital Cardiac Arrest