Clareo Health | Outcome of Use of a Novel Modulator of Oxidative Phosphorylation on Kidney Function in Patients With Progressive Chronic Kidney Disease
Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Neukidney Inc.
QRX-3 ( Eseronate ) is a formulated drug designed to supply and optimize NAD+ mitochondrial availability in order to target the loss of nephrons via renal fibrosis and tubular senescence of the kidney cells by enhancing the mitochondrial activity of these cells via the NAD/NAD+ redox pathway as well as reduce the presence of fibrogenic intracellular inflammatory markers . This novel drug therapy stabilized the intracellular oxidative phosphorylation process a pathway mechanism that is dysregulated or abnormal in the ongoing renal tubular cell injury and damage in chronic kidney disease.
In this study the investigators evaluate the effect of intervention with this novel drug therapy on a chronic kidney disease CKD population with slowly progressively declining renal function.
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Patient with Chronic kidney disease
Estimated Glomerular function by MDRD of less than 60mls/min
Patients with declining renal function ( as measured by eGFR by MDRD )
Rate of decline of eGFR over the last one year of less than 20%
Negative Serology markers for CKD etiology
Provider perceived adherence to study follow up
You may not be if
• Rapid rate of decline in kidney function of \> 20 % over last one year
* Symptomatic renal failure
* Presence of any suspected Acute renal failure superimposed
* Presence of cast , hematuria, or abnormal urinalysis outside of simple UTI
