Study of HS235 in Obese Patients With Pulmonary Hypertension and Heart Failure With Preserved Ejection Fraction (HFpEF)

Inclusion Criteria

• •Patients are eligible to be included in the study only if they meet at least all the following criteria:
• •1. Male or female, ≥ 18 years of age.
• •2. Ambulatory pulmonary artery pressure (PAP) monitoring (e.g. CardioMEMS™ HF System or Cordella™ HF System) implanted in the course of standard of care at least 90 days before Screening with mean pulmonary artery pressure (mPAP) ≥ 25 mmHg and diastolic pulmonary artery pressure(dPAP) ≥ 15 mmHg as averaged over the last 2 weeks prior to Randomization.
• •3. Established diagnosis of HFpEF with left ventricular ejection fraction (LVEF) ≥ 45 % as measured by echocardiography during Screening.
• •4. New York Heart Association (NYHA) class II or III heart failure symptoms.
• •5. Stable diuretic regimen during the screening period.
• •6. Kansas City Cardiomyopathy Questionnaire-Clinical Summary Score (KCCQ-CSS) \< 90 at screening.
• •7. 6-minute walking distance (6MWD) ≥ 100 m at screening.
• •8. Body mass index ≥ 30 to ≤ 50 kg/m2 and Body weight ≤140 kg.
• •9. Ability to adhere to study visit schedule and understand and comply with all protocol requirements.