A Study to Investigate the Effectiveness, Safety, and Tolerability of MAG200 Solution for Intra-articular Injection Compared With Placebo in Participants Aged 35 to 75 Years of Age With Symptomatic Osteoarthritis of the Knee.

Inclusion Criteria

• •1. Males and females aged ≥ 35 years to ≤ 75 years inclusive.
• •2. BMI ≥ 19.0 to ≤ 35.0 kg/m2.
• •3. Documented clinical diagnosis of OA of the study knee.
• •4. Documented radiological grading of Grade 2 or Grade 3 medial and/or lateral compartment OA of the study knee.
• •5. Documented radiological grading of OARSI JSN 1-2 of the medial and/or lateral compartment of the study knee.
• •6. Primary OA treatment of the study knee already attempted within the last 12 months, defined as:
• •1. Prescribed analgesia/anti-inflammatory medication where appropriate, AND
• •2. an attempted exercise program prescribed by a physical therapist (e.g., physiotherapist, osteopath) or medical practitioner for at least 8 weeks, AND
• •3. weight management, where appropriate.
• •7. Moderate to severe knee specific activity related pain score on the NRS for Pain over the past week.
• •8. Moderate to severe knee specific functional limitation on KOOS-PS.
• •9. Less than 5 degrees varus or valgus knee deformity of the study knee relative to neutral alignment.