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The Effect of Lymphatic Drainage Massage and Melatonin on Pain and Edema After Orthognathic Surgery.
Lymphatic drainage massage is one of the most essential techniques for reducing edema. It is a very gentle, monotonous, slow, rhythmic massage applied to the skin's surface. This technique accelerates the flow of lymphatic fluid, minimizing swelling and providing relief. Frequently used after orthognathic surgery, lymphatic drainage massage helps reduce edema, enhancing patients' postoperative comfort.
Melatonin, a hormone produced by the pineal gland, is a neurochemical substance that functions in harmony with the body's natural rhythm. In addition to its presence in the brain, melatonin can also be found in the retina, bone marrow, intestines, skin, and various blood cells. Conditions such as insomnia or jet lag may benefit from melatonin supplements. Beyond its role in improving sleep quality, melatonin also contributes to regulating the immune system, body temperature, blood pressure, and cortisol hormone levels. Another important function of melatonin is its powerful free radical-scavenging ability. It can neutralize both reactive oxygen species and reactive nitrogen species. Due to its strong antioxidant properties, several studies have investigated its effects on pain and edema. Research has shown that preoperative and postoperative melatonin administration can reduce postoperative pain and accelerate sensory recovery through its antioxidant effects.
Age
16 - 55 years
Sex
ALL
Healthy Volunteers
Yes
Bezmialem Vakıf Universty
Istanbul, Fatih, Turkey (Türkiye)
Start Date
March 30, 2025
Primary Completion Date
March 30, 2027
Completion Date
May 30, 2027
Last Updated
July 14, 2025
40
ESTIMATED participants
no intervention
OTHER
lymphatic drainage massage
OTHER
oral melatonin tablet
DIETARY_SUPPLEMENT
both melatonin and lymphatic drainage
COMBINATION_PRODUCT
Lead Sponsor
Bezmialem Vakif University
NCT06346132
NCT07351968
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