Fecal Microbiota Transplantation Via Oral Capsule for Treating Refractory Constipation in Parkinson's Disease

Exclusion Criteria

• •Individuals with cognitive impairment scoring less than 20 on the Korean version of the Mini-Mental State Examination (K-MMSE).
• •Individuals who have contraindications for fecal microbiota transplantation (acute infections, immunocompromised status, or a history of food allergies).
• •Individuals with ileus or colonic pseudo-obstruction.
• •Individuals with a history of major gastrointestinal surgeries, such as resection.
• •Individuals with suspected or confirmed gastrointestinal obstruction or gastric outlet obstruction.
• •Individuals with suspected or confirmed active gastrointestinal bleeding.
• •Individuals with gastrointestinal diseases requiring treatment or medical consultation.
• •Individuals receiving parenteral nutrition or enteral feeding.
• •Individuals experiencing dysphagia symptoms (difficulty swallowing, choking during meals, etc.).
• •Individuals who have taken antibiotics within 3 months prior to screening.
• •Individuals who have participated in other drug clinical trials within 3 months prior to screening.
• •Pregnant individuals.
• •Individuals with other severe diseases that may impair quality of life or the ability to perform daily activities.
• •Individuals with contraindications to the use of antibiotics (Ciprofloxacin, Metronidazole) as referenced in the text.
• •Any other case where the researcher deems participation in the clinical trial to be inappropriate for the subject.