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Resting-state Imaging and OSteoporosiS | Clinical Trials | Clareo Health

NOT_YET_RECRUITINGNA

Resting-state Imaging and OSteoporosiS

NCT07030205•University Hospital, Clermont-Ferrand

Summary

This study will be conducted in 20 postmenopausal healthy volunteers, 20 postmenopausal osteoporotic patients with fracture and 20 postmenopausal osteoporotic women without fracture, in order to compare functional connectivity between brain areas. Participants will complete different questionnaires and tests assessing cognition, quality of life, sleep, physical activity, pain, anxiety and depression. A biological sample will be performed in order to evaluate different markers of bone remodeling. A Resting-state functional magnetic resonance imaging (rs-fMRI) will be realized in order to establish functional connectivity between brain regions.

Eligibility

Age

50 - No limit years

Sex

FEMALE

Healthy Volunteers

Yes

Inclusion Criteria

•Women aged 50 or over, with postmenopausal osteoporosis, fractured or not, diagnosed by their rheumatologist,
•Able to give informed consent to participate in the research,
•Affiliation with the French Social Security.
•Women aged 50 or over,
•Bone densitometry performed as part of the protocol, not suggestive of osteoporosis and validated by investigators,
•Matched to patients by age, menopausal status, socio-educational level and manual laterality,
•Able to give informed consent to participate in the research,
•Affiliation with the French Social Security.
•Registration or acceptance of registration in the national register of volunteers participating in Research.

Exclusion Criteria

•Presence of pacemaker,
•Presence of medical devices (implants or prostheses),
•Incompatibility of the patient with the safety criteria of the medical imaging center for carrying out magnetic resonance experiments at 3 Tesla,
•Contraindications to the realization of MRI without injection such as claustrophobia proven, hearing aid, pacemaker wearers, wearing a brain clip,
•Refusal to be informed in the event of the accidental discovery of an anomaly during the resting state functional magnetic resonance imaging,
•Woman under legal protection or deprived of liberty,
•Refusal to participation

Locations (1)

CHU de Clermont-Ferrand

Clermont-Ferrand, France

Key Dates

Start Date

July 1, 2025

Primary Completion Date

December 1, 2026

Completion Date

December 1, 2027

Last Updated

June 22, 2025

Enrollment

ESTIMATED participants

Conditions

Osteoporosis

Interventions

Blood sample

OTHER

Bone density exam

OTHER

Tests and questionnaires of study

OTHER

Functional connectivity value of brain networks at rest

OTHER

Contacts

Lise Laclautre

CONTACT

334.73.754.963 promo_interne_drci@chu-clermontferrand.fr

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 22, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

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Resting-state Imaging and OSteoporosiS

Inclusion Criteria

Exclusion Criteria

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