Effects of Transcranial Electrical Stimulation on Cognitive Impairment in CNS Inflammatory Demyelinating Diseases

Exclusion Criteria

• •1. Relapse record within the past month;
• •2. Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques;
• •3. Participating in any other clinical research within 1 month prior to enrollment or currently;
• •4. Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices;
• •5. Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives;
• •6. History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;
• •7. Pregnant or lactating women, or those planning pregnancy in the near future;
• •8. Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness;
• •9. Concurrent severe or unstable organic diseases;
• •10. Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance;
• •11. Other situations deemed inappropriate for study participation by the researchers.