Transcranial Electrical Stimulation for Treating Chronic Pain in Inflammatory Demyelinating Diseases

Exclusion Criteria

• •A history of relapse within the past month;
• •Recent medication adjustments or treatment with modified electroconvulsive therapy, transcranial magnetic stimulation, or other neurostimulation techniques within the past month;
• •Participation in any other clinical trial within the past month or currently participating in another clinical trial;
• •Presence of cochlear implants, pacemakers, or implanted stimulators in the brain;
• •Skin integrity at the electrode placement site is compromised, or allergy to electrode gel or adhesive;
• •A history of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections;
• •Pregnant or breastfeeding women, or those planning to become pregnant in the near future;
• •A score of ≥3 on item 3 (suicide item) of the HDRS-17, or a history of severe psychiatric disorders;
• •Presence of severe or unstable organic diseases;
• •Poor patient compliance preventing cooperation with treatment, follow-up, or clinical, EEG, and imaging data collection;
• •Any other situation deemed unsuitable for participation in the study by the investigator.