Nikhil Ahluwalia, MBBS, PhD

CONTACT

Lead Sponsor

University College, London

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

No

•PVC Cohort
•Age \> 18 years old.
•Participants must understand and be willing to sign a written informed consent document.
•PVC burden of \>10% in a 24-hour period on Holter monitoring.
•Participants with structural heart disease and a transvenous implantable cardioverter defibrillator (ICD) in situ
•At least three clinically significant VT events (VT events defined as either \>30 seconds of sustained VT, appropriate ICD ATP therapies or appropriate ICD shocks) in the six months before enrolment

•Coronary artery disease
•Known cardiac disease (heart failure or cardiomyopathy) in the documented absence of PVCs. Individuals with suspected PVC-induced cardiomyopathy heart failure, defined as cardiomyopathy or heart failure only diagnosed in the setting of a \>10% PVC burden, will be allowed to participate.
•A known diagnosis of Epilepsy.
•Ongoing pregnancy or intention to become pregnant in the forthcoming 12 months.
•Participants using a TENS device for any indication
•VT cohort
•Heart failure syndrome with inotrope dependency or requiring mechanical assistance.
•Reversible cause of arrhythmia (e.g. culprit electrolyte abnormality or toxin)
•NYHA (New York Heart Association) stage IV heart failure
•Myocardial infarction or cardiac surgery in the last six months
•Life expectancy \<12 months
•Ongoing pregnancy or intention to become pregnant in the forthcoming 12 months.
•Participants using a TENS device for any indication