Prophylactic Anti-aRrhythmic Therapy With Amiodarone in Critically Ill Patients Admitted for an Out-of-hospital Cardiac Arrest With Initial Shockable Rhythm

Exclusion Criteria

• •1. Cardiac arrest secondary to an extra-cardiac cause (suspected or confirmed)
• •2. Indication for amiodarone decided by the physician at ICU admission
• •3. No central venous catheter available for continuous infusion of amidoarone
• •4. Thyroid disease under treatment
• •5. History of cardiac conduction disorders, not treated by permanent pacemaker
• •6. Any contra indication to amiodarone treatment
• •7. Refractory ventricular arrhythmia or electrical storm
• •8. Need for veno-arterial extracorporeal membrane oxygenation (VA-ECMO) at admission
• •9. Known limitations in therapy and Do Not Resuscitate-order
• •10. Moribund patient due to pre-arrest history (estimated life expectancy \< 3 months)
• •11. Pregnant or breastfeeding women
• •12. Patient needing a nadolol treatment due to QT long syndrome or catecholaminergic polymorphic ventricular tachycardia
• •13. Patient with known pulmonary fibrosis
• •14. Patient with known interstitial lung disease