Loading clinical trials...

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli | Clinical Trials | Clareo Health

RECRUITINGNA

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

Visual Perception in Visual Snow Syndrome

NCT06961864•University of Minnesota

View on ClinicalTrials.gov

Summary

The goal of this study is to learn more about the brain pathways and activity involved in creating Visual Snow Syndrome (VSS). The main questions it aims to answer are: * Does VSS arise from spontaneous activity in brain pathways? * Where in the brain does the activity contributing to VSS arise? * How does brain activity contribute to VSS? Participants will: 1. Undergo assessments and questionnaires to understand visual and mental symptoms, cognitive, and sensory function. 2. Make visual judgements based on images presented to them both inside and outside a magnetic resonance imaging (MRI) machine. 3. Undergo scanning of their brain while inside of an MRI machine.

Eligibility

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Between the ages of 18 and 60 years old
•Normal (20/25 or better in each eye) or corrected-to-normal vision (MR-compatible glasses will be provided as needed)
•Ability to comply with study instructions
•Individuals who have a current diagnosis of VSS from a neuro-ophthalmologist or meet diagnostic criteria of VSS (experience of dynamic dots across the visual field persisting longer than 3 months and at least 2 of the following additional visual symptoms: palinopsia, entoptic phenomena, trails behind moving objects, photophobia, or nyctalopia)
•Individuals living in Minnesota within 2 hours of the study site
•Between the ages of 18 and 60 years old
•Normal (20/25 or better in each eye) or corrected-to-normal vision (MR-compatible glasses will be provided as needed)
•Ability to comply with study instructions
•Individuals living in Minnesota within 2 hours of the study site

Exclusion Criteria

•Not being fluent in English or another language for which interpretation/translation services are available
•A diagnosed or self-reported intellectual disability
•Current substance dependence (besides nicotine), or drug dependence with tolerance or withdrawal within past 12 months
•Hallucinogenic substance use within the past 12 months or hallucinogenic substance use within 12 months prior to onset of VSS symptoms
•Severe central nervous system disease
•Head injury with skull fracture or loss of consciousness for more than thirty minutes
•Presence of a physical problem that would render study measures difficult or impossible to administer or interpret (e.g., visual field loss)
•Age less than 18 years or greater than 60 years
•MRI exclusions (for MR visits only):
•* Metal in the body that cannot be approved by the CMRR safety committee
+27 more criteria

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Key Dates

Start Date

April 11, 2025

Primary Completion Date

March 31, 2030

Completion Date

March 31, 2030

Last Updated

January 14, 2026

Enrollment

100

ESTIMATED participants

Conditions

Visual Snow SyndromeMigraineHealthy

Interventions

Visual Adaptation

BEHAVIORAL

Assessments and Questionnaires

BEHAVIORAL

Functional Magnetic Resonance Imaging (fMRI)

DEVICE

Magnetic Resonance Imaging (MRS)

DEVICE

Contacts

Michael-Paul Schallmo, Ph.D.

CONTACT

(612) 273-9130 schallmolab@umn.edu

Hannah Moser, Ph.D.

CONTACT

schallmolab@umn.edu

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

NCT07310264

Healthy Volunteers (HV)Parkinson's Disease (PD)

View study

RECRUITINGNA

A New Portable Device for Non-invasive Ventilatory Support

NCT06716502

HealthyRespiratory Disease

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 14, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Investigating Brain Function in People With and Without Visual Snow Syndrome Using Adaptation to Visual Stimuli

Inclusion Criteria

Exclusion Criteria

Research Into the Safety of a New Agent (VT-5006) in People With and Without Parkinson's Disease

A New Portable Device for Non-invasive Ventilatory Support

Fecal Microbiota Transplantation for Patients With Autism Spectrum Disorder.

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Collection of Data and Samples From Healthy Donors for Use in Translational Research