Clinically premenopausal (defined as having active, regular menstruation without vasomotor symptoms)
At least one of two ovaries readily visualized on diagnostic CT or MR imaging as confirmed by radiologist
Planning to receive radiation therapy (for any indication)
Ability to understand and willingness to sign an IRB-approved written informed consent document.
You may not be if
Prior pelvic radiation
Prior cancer therapies that are known to impact ovarian function
Prior diagnosis of ovarian insufficiency/failure or menopause
Clinically peri- or post-menopausal
* For patients \> 45 years old, if there is a clinical history of vasomotor symptoms OR irregular periods, then the patient must be excluded.
* For patients ≤ 45 years old, if there is a history of vasomotor symptoms consistent with menopause OR irregular menstruation for ≥3 months OR recent changes in their menstrual cycle \> 14 days, then the patient must be excluded.
