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Effects of Oropharyngeal-topical and Intravenous Lidocaine on the Optic Nerve Sheath Diameter Changes After Endotracheal Intubation: a Randomized Controlled Clinical Study
This study aims to evaluate the effects of pre-intubation oropharyngeal topical lidocaine on optic nerve sheath diameter (ONSD) post-endotracheal intubation. The study will measure the ONSD using ultrasonography before intubation, and at 1, 5, and 10 minutes post-intubation. The results will be compared between patients receiving %10 lidocaine topically and %2 intravenous lidocaine.
Increased intracranial pressure (ICP) is a critical condition that requires early and accurate assessment. Traditional invasive ICP monitoring techniques, such as lumbar puncture and intracranial pressure monitoring devices, carry significant risks. Optic nerve sheath diameter (ONSD) measurement via ultrasonography is a non-invasive method that reflects increased ICP. Patients will be divided into two groups: Group A will receive %10 topical oropharyngeal lidocaine, and Group B will receive %2 intravenous lidocaine. The primary aim of the study is to evaluate the impact of lidocaine on ONSD at 1, 5, and 10 minutes post-intubation and to compare the effects on the two groups.
Age
18 - 65 years
Sex
ALL
Healthy Volunteers
No
Ankara Bilkent City Hospital
Ankara, Turkey, Turkey (Türkiye)
Start Date
March 20, 2025
Primary Completion Date
November 30, 2025
Completion Date
November 30, 2025
Last Updated
March 13, 2025
190
ESTIMATED participants
Optic nerve sheath diameter measurement 0
DIAGNOSTIC_TEST
optic nerve sheath diameter measurement 1
DIAGNOSTIC_TEST
optic nerve sheath diameter measurement 2
DIAGNOSTIC_TEST
optic nerve sheath diameter measurement 3
DIAGNOSTIC_TEST
Pre-intubation oropharyngeal topical %10 lidocaine
PROCEDURE
Pre-intubation intravenous %2 lidocaine
PROCEDURE
Lead Sponsor
Ankara City Hospital Bilkent
NCT06979999
NCT06254534
Data Source & Attribution
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