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Introduction: Possible consequences of endotracheal intubation are post-intubation voice changes. Hypothesis: Endotracheal intubation during head and neck surgery is associated with objective and perceptual voice disorders. Research objective: To investigate the short-term and long-term effects of endotracheal intubation on voice quality during head and neck surgery. Material, subjects, methodology and research design: A prospective observational cohort study that will include patients undergoing surgery and endotracheal intubation lasting up to 3 hours. Adult patients divided into three groups will be included in the research: thyroid surgery, parotid gland surgery and abdominal surgery. Videostroboscopy, perceptual and objective acoustic voice analysis will be recorded before surgery, on the second postoperative day, two weeks and 1 month after surgery. Expected scientific contribution of the proposed research: The scientific contribution would be an understanding of the risk factors and the connection of voice disorders after endotracheal intubation, as well as the ability to determine differences in this risk in patients undergoing different operations.
study protocol has been published and is attached below
Age
18 - 70 years
Sex
ALL
Healthy Volunteers
Yes
University Hospital Centre Zagreb
Zagreb, Croatia
Start Date
September 25, 2024
Primary Completion Date
December 31, 2025
Completion Date
March 30, 2026
Last Updated
August 20, 2025
180
ESTIMATED participants
Lead Sponsor
Clinical Hospital Centre Zagreb
NCT06765941
NCT06931743
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