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The main purpose of this study is to compare patients with a deep bleed in the brain undergoing surgery to patients receiving routine medical care. The standard treatment involves admission to the Intensive Care Unit (ICU) with close monitoring and blood pressure control. It also includes other medical (non-surgical) treatments to prevent more bleeding or another stroke. Sometimes, doctors will recommend surgery to remove the blood if medical treatment alone is not successful. There is evidence that doing minimally invasive surgery early-using a small opening in the skull to remove blood-may help some patients. Researchers aim to understand whether this surgery is better than current medical treatment, which may include surgeries to relieve pressure on the brain in some cases. This study, called REACH, is comparing usual medical care to early minimally invasive surgery so doctors can know which is better for patients.
The REACH trial, which stands for Rapid Evacuation and Access of Cerebral Hemorrhage Trial, is a medical research study aimed at finding better ways to treat people who have had a specific type of stroke called an intracerebral hemorrhage. This type of stroke happens when a blood vessel bursts and causes bleeding in the brain. Traditionally, treating this kind of stroke has been challenging, and the best approach is not always clear. Recently, trials have shown that minimally invasive surgery to remove the clot caused by bleeding improves outcomes and decreases death when the blood is located closer to the surface of the skull. The REACH trial is testing the same minimally invasive surgery to remove the blood clot caused by the bleeding in a deeper part of the brain. The goal is to see if this approach can improve recovery and outcomes for patients compared to standard medical care. In simple terms, the REACH trial is trying to find out if using a less invasive surgical technique can help people recover better and faster after a bleeding stroke in the deeper part of the brain.
Age
18 - 70 years
Sex
ALL
Healthy Volunteers
No
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States
Stanford University Medical Center
Palo Alto, California, United States
Baptist Health Jacksonville FL
Jacksonville, Florida, United States
Baptist Health South Florida
Kendall, Florida, United States
Jackson Memorial Hospital (JMH)
Miami, Florida, United States
Grady Memorial Hospital
Atlanta, Georgia, United States
Emory Hospital Midtown
Atlanta, Georgia, United States
Emory University Hospital (EUH)
Atlanta, Georgia, United States
Rush University
Chicago, Illinois, United States
Endeavor Health, Northshore
Evanston, Illinois, United States
Start Date
May 27, 2025
Primary Completion Date
March 1, 2030
Completion Date
March 1, 2030
Last Updated
March 19, 2026
600
ESTIMATED participants
Surgical management
PROCEDURE
Medical Management
OTHER
Lead Sponsor
Emory University
Collaborators
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and ConditionsNCT04956185