Transnasal Induction of Normothermia for Neurogenic Fever

Exclusion Criteria

• •1. Intubation is contraindicated.
• •2. Weight of ≤ 100lb or ≥ 250lb.
• •3. Active/ongoing epistaxis.
• •4. Known or suspected pregnancy.
• •5. Participation in another ongoing investigational study.
• •6. Prisoners and/or patients for whom no LAR is available.
• •7. Patient is in airborne/droplet disease isolation protocol.
• •8. Patient is or suspected to be immunocompromised.
• •9. Nasal septal deviations (per standard of care CT scan; any degree).
• •10. Chronic rhinosinusitis.
• •11. Traumatic brain injury.
• •12. Prior skull-base surgery.
• •13. Penetrating cranial trauma.
• •14. Recent nasal trauma or anterior base skull fracture.
• •15. Any condition for which transnasal air flow would be contraindicated.
• •16. Refractory hypoxemia (partial pressure of oxygen in arterial blood (paO2) below 60 torr or oxyhemoglobin saturation below 90% despite endotracheal intubation, mechanical ventilation, and provision of supplemental oxygen of up to 0.60).
• •17. Refractory hypercarbia (partial pressure of carbon dioxide in arterial blood (paCO2) above 50 torr despite endotracheal intubation and conventional mechanical ventilation).