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Study on Blood Pressure Variability and Frailty in the Older People: the HypoPHrail Study
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events)
Observational prospective single-center, non-profit study. Primary objective of the study: To determine if the hypotensive phenotype, defined as one episode of daytime systolic blood pressure (SBP) \<90 mmHg (or two episodes of daytime SBP \<90 mmHg, if mean 24 h SBP is \<125 mmHg) detected at Ambulatory Blood Pressure Monitoring (ABPM) is associated with adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events) Secondary objectives of the study: * To examine the association between home Blood Pressure Variability (BPV) and frailty, assessed using various tools for assessing frailty * To examine the association between short term BPV and adverse events at follow up (death, hospitalization, falls, emergency room admission for uncontrolled hypertension, major cardiovascular events) * To determine the prevalence of hypotensive phenotype according to frailty status in hypertensive individuals.
Age
75 - No limit years
Sex
ALL
Healthy Volunteers
No
Istituto Auxologico Italiano IRCCS
Milan, Italy
Start Date
July 15, 2024
Primary Completion Date
July 15, 2027
Completion Date
July 15, 2027
Last Updated
March 10, 2025
220
ESTIMATED participants
Diagnostic tests and questionnaires
DIAGNOSTIC_TEST
Lead Sponsor
Istituto Auxologico Italiano
Data Source & Attribution
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