Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
McMaster University
Age
18–any
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Males and females (≥18 years old)
Asthma: Respiratory physician confirmed diagnosis of moderate-to-severe asthma and Historical objective evidence of asthma and/or specialist/respirologist confirmation (post-bronchodilator reversibility and/or methacholine bronchoprovocation test \<8 mg/mL)
COPD: Respiratory physician confirmed diagnosis of COPD that is moderate-to-severe according to GOLD criteria (post-bronchodilator FEV1/FVC\<LLN and FEV1\< 80%pred) and CAT score ≥10 or mMRC score ≥ 2
Chronic cough: Refractory Chronic Cough (RCC) and Unexplained Chronic Cough (UCC) lasting \>1 year with Normal chest radiograph and no airflow obstruction (FEV1/FVC \>Lower Limit of Normal)
Healthy participants: No history of respiratory disease or other pulmonary disorders and no use of inhaled medications or corticosteroids with normal spirometry and Modified Medical Research Council (mMRC) Dyspnea Scale =\<1
You may not be if
Pregnant or breastfeeding
Current smoker or \>10 yr pack history or smoked within the last 6 months
Exacerbation within 4 weeks of recruitment
Preterm birth (≤36 weeks gestation) or perinatal complications
Memory, cognitive, or psychiatric limitations that may prevent optimal participation
Treatment with current biologic therapy: anti-IgE mAb within 130 days, anti-IL-4/4R, IL-5/5R, IL-13, or TSLP within 2 months or 5 half-lives whichever is longer prior to visit 1
