Budesonide as a Treatment for Functional Dyspepsia

Exclusion Criteria

• •1. Patients with any condition which, in the opinion of the investigator, makes the patient unsuitable for entry into the study
• •2. Patients with any major psychiatric disorders (including those with a major psychosomatic element to their gastrointestinal disease), depression, alcohol or substance abuse in the last 2 years
• •3. Patients presenting with predominant symptoms of irritable bowel syndrome (IBS) or of gastro-esophageal reflux disease (GERD)
• •4. Presence of diabetes mellitus, celiac disease (diagnosed with presence of anti-tissue transglutaminase antibodies and anti-gliadin antibodies or via duodenal biopsies), lupus, scleroderma or other systemic auto-immune disease
• •5. Patients with eosinophilic esophagitis or eosinophilic gastroenteritis
• •6. Active H. Pylori infection (or \< 6 months after eradication)
• •7. Organic gastro-intestinal disease of history of gastrointestinal surgery other than appendectomy
• •8. Known impaired liver dysfunction
• •9. Drugs altering gastric emptying, anti-inflammatory drugs, acid suppressive drugs or some drugs altering the CYP3A4 metabolism
• •10. Major change in diet last 3 months
• •11. Females who are pregnant or lactating
• •12. Patients not capable to understand or be compliant with the study