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The Temporally Interfering in Patients with Disorders of Consciousness | Clinical Trials | Clareo Health

NOT_YET_RECRUITINGNA

The Temporally Interfering in Patients with Disorders of Consciousness

The Efficacy and Safety of Temporally Interfering in Patients with Disorders of Consciousness

NCT06822192•Zhejiang Provincial People's Hospital

View on ClinicalTrials.gov

Summary

This project will help the patient recover consciousness by giving TI (temporally interfering) treatment

Eligibility

Age

18 - 75 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•In accordance with the international diagnostic criteria for MCS formulated by Giacino in 2002 or the diagnostic criteria for UWS proposed by Laureys in 2010; Patients with disease duration ≥28 days and unconscious improvement tendency in the past one month; No use of any sedative drugs or antiepileptic drugs (sodium or calcium channel blockers) in the past 1 month; stable vital signs; No obvious brain edema, hydrocephalus, and severe brain atrophy; Age from 18 to 70 years old; Informed consent was obtained from the patients' family members.

Exclusion Criteria

•Previous history of neurological or psychiatric disorders; Previous history of traumatic brain injury; History of cancer; Taking sedative drugs or antiepileptic drugs in the past 1 month; Unstable vital signs; Skull defect; The patients' family members did not sign the informed consent.

Key Dates

Start Date

February 20, 2025

Primary Completion Date

December 31, 2025

Completion Date

December 31, 2026

Last Updated

February 12, 2025

Enrollment

ESTIMATED participants

Conditions

Disorders of Consciousness

Interventions

temporally interfering electrical stimulation

DEVICE

Contacts

Li Zhang

CONTACT

+86-13732274598 zhangli0407@zju.edu.cn

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 12, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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The Temporally Interfering in Patients with Disorders of Consciousness

Inclusion Criteria

Exclusion Criteria

Spontaneous Eye Blinking in Disorders of Consciousness

Brain Network Analysis of Anesthesia Characteristics in Patients With pDoC Based on PSG

mindBEAGLE: Unlocking Functional Communication for Patients With Disorders of Consciousness

Spontaneous Eye Blinking Evaluation for Cognitive Assessment of Individuals With Severe Acquired Brain Injury

Robot-assisted Training After Acquired Brain Injury and Disorders of Consciousness

Stellate Ganglion Block on Postoperative Sleep Status in Patients With Prolonged Disorders of Consciousness