National Institute of Neurological Disorders and Stroke (NINDS)
Aim 1: Determine neurobehavioral responses to LIFUP in patients with DoC. Aim 2: Determine neurophysiologic (EEG) responses to LIFUP in patients with DoC.
Aim 3: Identify and evaluate ethical perspectives of patient representatives (family members and surrogate decision-makers) surrounding investigation of therapeutic neuromodulation technologies such as LIFUP in patients with DoC.
Advanced MRI will be obtained to determine predictive neuroimaging signatures of responsiveness. This project will crucially inform the groundwork for a personalized, connectome-based approach to impactful therapeutic intervention for patients affected by DoC due to diverse pathologies across the brain injury care continuum and will inform an ethical framework for responsible development and deployment of therapeutic neuromodulation technologies.
Age
18–79
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Brain injury resulting in DoC diagnosis, following international guidelines
At least 18 years of age
Legally authorized representative (surrogate) available to consent
You may not be if
History of neurological disorder other than the brain injury
Metal implant or other condition precluding MRI
Manifest continuous spontaneous movement (which would prevent safe/successful MRI)
