Childhood-Onset Essential Hypertension Natural History Study

Study Description: This study seeks to identify molecular processes and genetics that contribute to the development of childhood-onset essential hypertension (COEH) in a diverse cohort of children. Identification of blood pressure (BP)-regulating pathway(s) involved in COEH will allow for targeted and individualized therapy. Objectives: Primary Objective: Elucidate the molecular genetic processes associated with developing COEH. Secondary Objective: Characterize the vascular, clinical, and laboratory phenotypes seen in patients with COEH. Endpoints: Primary Endpoint: Evidence that saturation of the allelic spectrum for COEH has been reached. Secondary Endpoint: Completion of exhaustive phenotyping on COEH patients.