Efficacy of Antibiotic Treatment for Patients With Chronic Low Back Pain and Modic Type I Changes - Randomized Placebo-controlled Trial

Inclusion Criteria

• •Aged 18-65 years.
• •Chronic low back pain (i.e. duration \>6 months) after a previous (MRI confirmed) disc herniation within the past 6 months to 2 years.
• •At least 2 of the following questions should be answered with "Yes":
• •* Does training and/or exercise increase your pain?
• •* Is your sleep during the night disturbed due to your back pain?
• •* Is it painful to turn over in bed at night?
• •* Do you suffer from morning pain?
• •The mean pain intensity should be at least 5 points on a 0-10 NRS-scale, calculated as the mean pain intensity of 3 indices: current pain, worst pain within the preceding two weeks, and the usual mean pain within the preceding two weeks.
• •Modic Type I changes visible on the MRI-scan in the vertebrae adjacent to the previous herniated disc.