Phase 1 Study to Evaluate the Safety and Tolerability of EO1404 in the Treatment of Corneal Edema

Exclusion Criteria

• •All ocular criteria apply to study eye unless otherwise noted.
• •1. Other corneal disease, including active or prior herpetic ocular infection; active inflammation; corneal scarring from trauma, burns, or infection; or band keratopathy.
• •2. Visual acuity in the fellow eye is worse than 20/200.
• •3. Anterior chamber intraocular lens.
• •4. Subject requires topical, intravenous or oral acyclovir and/or related products during study duration
• •5. History of vitrectomy.
• •6. History of refractive surgery.
• •7. Macular disease that in the investigator and/or sponsor's opinion would limit the ability of the subject to demonstrate improvement in BCVA.
• •8. Prior incisional eye surgery within 3 months prior to study treatment.
• •9. Subject is receiving systemic steroids or other systemic immunosuppressive medications.
• •10. Subject is currently participating in or has participated within the last 3 months in any other clinical trial of an investigational drug by ocular or systemic administration.
• •11. History of uveitis or other ocular inflammatory disease.
• •12. History of glaucoma, or peripheral anterior synechiae on gonioscopy.
• •13. History of incisional glaucoma surgery (e.g., trabeculectomy, glaucoma drainage implant).
• •14. Female subject who is pregnant, nursing, or planning to become pregnant, or who is of childbearing potential and not using a reliable means of contraception during the study.
• •15. Subject is immunodeficient, or tested positive for HIV.
• •16. Subject is on chemotherapy.
• •17. History of malignancy other than basal cell carcinoma, UNLESS the malignancy was treated successfully 5 years prior to inclusion in the study.
• •18. History of ocular neoplasm.