Lisca F Wurfbain, MD - PhD

CONTACT

Lead Sponsor

Amsterdam UMC, location VUmc

Age

50 - No limit years

Sex

FEMALE

Healthy Volunteers

No

•Female ≥ 50 years with an ipsilateral invasive recurrent breast cancer event after previous breast-conserving surgery and postoperative whole breast irradiation
•World Health Organization performance status 0-2
•Tumor size ≤ 2 cm and unifocal on MRI
•Tumor histology as assessed on biopsy:
•Bloom-Richardson grade 1 or 2 Non-lobular invasive histological type carcinoma Estrogen receptor positive HER2 receptor negative No lymphovascular invasion
•No extensive DCIS (outside tumor size of 2 cm) on mammography or tumor biopsy, including non-mass enhancement on MRI
•Clinical node negative on 18-F FDG PET-CT, ultrasound and MRI
•No distant metastasis
•No or mild late toxicity (no grade 2 or higher) from previous breast-conserving therapy
•Adequate understanding of the Dutch language

•Ipsilateral invasive breast cancer event less than two years after first breast-conserving therapy for breast cancer
•Other malignancy within 5 years before ipsilateral breast recurrence diagnosis. For carcinoma in situ no specific time span to ipsilateral breast recurrence diagnosis is required for inclusion
•Known breast cancer mutation gene carrier
•Collagen synthesis disease (e.g. osteogenesis imperfect, Ehlers-Danlos syndrome, systemic sclerosis)
•Previous ipsilateral mastectomy
•Invasive lobular carcinoma, DCIS without invasive cancer
•MRI absolute contraindications
•Indication for treatment with neoadjuvant chemotherapy
•Legal incapacity

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