Severe Asthma Network Italy

Inclusion Criteria

• •1. signed informed consent and privacy disclaimer;
• •2. age \> 12 years;
• •3. diagnosis of severe asthma according to the ERS/ATS criteria:
• •1. During treatment with:
• •* High-dose ICS + at least one addistional controller (LABA, montelukast, or theophylline) or
• •* Oral corticosteroids \>6 months/year
• •2. at least one of the following occurs or would occur if treatment would be reduced:
• •* ACT \<20 or ACQ\>1.5
• •* At least 2 exacerbations in the last 12 months
• •* At least 1 exacerbation treated in hospital or requiring mechanical ventilation in the last 12 months
• •* FEV1 \<80% (if FEV1/FVC below the lower limit of normal)