Local Methotrexate Injections for the Treatment of Nail Psoriasis

Intralesional Methotrexate Injections for the Treatment of Nail Psoriasis: an Intra-subject Randomized Controlled Trial

NCT06578728•Weill Medical College of Cornell University

View on ClinicalTrials.gov

Summary

The investigators hope to learn the efficacy of methotrexate injections for treatment of nail psoriasis.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Subject must be at least 18 years of age
•Subject must have nail psoriasis that is clinically diagnosed in at least 3 fingernails

Exclusion Criteria

•Subject with any clinically significant condition or situation, other than the condition being studied that, in the opinion of the investigator, would interfere with study evaluations or optimal participation in the study. This is including, but not limited to: immunodeficiency, onychomycosis, any other nail condition other than psoriasis, allergy to methotrexate, triamcinolone acetonide, local anesthetic, normal saline, or any other material used for procedures
•Subject who has received radiation therapy, chemotherapy, and/or immunosuppressive drugs within 6 months of study, and/or oral corticosteroids or IV methotrexate for \>1 month within the 6 months of study (exception inhaled steroids);
•Subjects who use substances (medications, supplements, ect) known to significantly interact with drugs used as intervention in the study
•Subject who is pregnant, breastfeeding, or planning to get pregnant
•Subject known to have received treatment with investigational drugs or devices within 30 days prior to enrollment into this study
•Subject who is on systemic treatment for psoriasis
•Subject with baseline abnormalities in liver function tests or complete blood count
•Subjects with diagnosis of renal insufficiency or impairment
•Subject who is unwilling to abstain from any cosmetic nail treatments outside those provided by the study clinic, beyond basic nail trimming (i.e. no spa nail treatments, no nail polish use, no other topical prescription nail medication)
•Subject who is unwilling to abstain from any medical nail treatments on their nails other than the study intervention (i.e. topical steroids, antifungal creams) for the duration of the study intervention and for duration of the washout period (if applicable)
+1 more criteria

Locations (1)

Israel Englander Department of Dermatology

New York, New York, United States

Key Dates

Start Date

September 10, 2025

Primary Completion Date

January 1, 2026

Completion Date

January 1, 2026

Last Updated

September 25, 2025

Enrollment

ESTIMATED participants

Conditions

Nail Psoriasis

Interventions

Methotrexate

DRUG

Triamcinolone Acetonide 10mg/mL

DRUG

Saline

DRUG

Topical Use of 2% Tofacitinib for Nail Psoriasis: an Exploratory Clinical Study

NCT07313072

Nail Psoriasis

View study

UNKNOWNNA

Methotrexate Alone vs Combination With Excimer Light in Nail Psoriasis

NCT06150794

Nail Psoriasis

View study

UNKNOWNNA

Nd:YAG Laser and Radiofrequency in Treatment of Fingernail Psoriasis

NCT05695833

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 25, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions