Impact of Urolithin A (Mitopure) on Mitochondrial Quality in Muscle of Frail Older Adults

Exclusion Criteria

• •Participants must not have:
• •Participated in a clinical trial within 90 days of screening or more than 4 times in the previous year.
• •A history (within 3 months of screening) of alcohol consumption exceeding 2 standard drinks per day on average (1 standard drink = 10 grams of alcohol).
• •A history or presence of allergy to 5-aminolevulinic acid or porphyrins.
• •A history or presence of allergy to lidocaine.
• •Positive hepatitis B surface antigen (HBsAg), hepatitis C antibody (HCV Ab), or human immunodeficiency virus antibody (HIV Ab) at screening.
• •Unwillingness or inability to refrain from consuming alcohol within 48 hours before each visit until the end of said visit.
• •Unwillingness or inability to refrain from consuming 8 or more units of xanthine containing beverages and foods per day during the entire study.
• •Unwillingness to not consume other mitochondrial supplements during the course of the study (such as CoQ10, reseveratrol, NR, NMN etc.) and pomegranate juice
• •unwillingness to not change diet or physical activity levels during the course of the study
• •Unwillingness or inability to undergo a muscle biopsy.
• •Underlying chronic disease, which in the opinion of the investigator, would interfere with study participation or the validity of the measurements.
• •Unintentional weight loss ≤5% of regular body weight during the last 6 months.
• •Medication requirements that may interfere with the interpretation of the results.
• •Loss or donation of blood over 500mL three months prior (male subjects) or four months prior (female subjects) to participating in the study.
• •Smoked (tobacco and/or marijuana mixed with tobacco (THC)) within 6 months prior to the start of the study;
• •Abused drugs, medicine or alcohol within up to 30 days prior to the start of the study (Alcohol: more than 10 drinks a week, with more than 2 drinks a day most days; Drugs: THC, cocaine, opiates, amphetamines/methamphetamines, benzodiazepines, barbiturates, Buprenorphine, Creatin, Methadone metabolite, oxycodone, phencyclidine);
• •A positive COVID-19 test taken 1 week to 24h before study start date.