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Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors

Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors: A Prospective Study

NCT06531265•Sohag University

Summary

This study was to assess the diagnostic yield and the safety of bronchoscopic cryotechniques in the management of endobronchial tumors.

Detailed Description

Novel flexible cryoprobes were introduced for tissue sampling during bronchoscopy. Employing this approach, the sample is collected when frozen, with the tissue attached to the frozen end of the probe. This approach enables the retrieval of larger tissue samples from endobronchial lesionsEndobronchial cryotherapy is employed to treat individuals with obstructive central bronchial lung cancers. It has been demonstrated to effectively recanalize obstructed respiratory passages, alleviate symptoms, and improve the quality of life for patients in advanced stagesThis study aimed to assess the effectiveness and safety of using bronchoscopic cryotechniques for diagnosing and treating endobronchial malignancies.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•patients with radiologically suspected endobronchial masses

Exclusion Criteria

•Patients with contraindications to bronchoscopy.
•uncorrected coagulopathy (if the international normalized ratio (INR) is more than 1.5).
•severe refractory hypoxemia (even after administering the highest possible dose of oxygen, the partial pressure of oxygen ("PaO2") stays below 70 mm Hg.
•hypoventilation with hypercapnia (type 2 respiratory failure).
•severe pulmonary hypertension \> 55 mmHg by echocardiography.
•hemodynamic instability.

Locations (2)

Sohag University

Sohag, Egypt

Sohag University

Sohag, Egypt

Key Dates

Start Date

July 1, 2019

Primary Completion Date

October 30, 2022

Completion Date

October 30, 2022

Last Updated

July 31, 2024

Enrollment

ACTUAL participants

Conditions

Cryotherapy EffectBronchial Neoplasms

Interventions

Endobronchial cryobiopsy and cryotherapy using flexible bronchoscopy

PROCEDURE

Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection

NCT05348447

Cryotherapy EffectPain, Postoperative

View study

TERMINATED

Evaluation of a New Open Source Virtual Bronchoscope Navigation System

NCT03745859

Bronchial Neoplasms

View study

TERMINATEDPHASE1

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: July 31, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Cryotechnique as a Diagnostic and Therapeutic Tool of Endobronchial Tumors

Inclusion Criteria

Exclusion Criteria

Intercostal Nerve Cryotherapy in Patients Undergoing Minimally Invasive Pulmonary Resection

Evaluation of a New Open Source Virtual Bronchoscope Navigation System

(Concerto) Study of BLU-451 in Advanced Cancers With EGFR Exon 20 Insertion Mutations

The Effect of Brief Skin Cooling on Isometric Muscle Strength

(HARMONY) Study of BLU-701 in EGFR-mutant NSCLC

Acute Effects of Cryotherapy Duration in Healthy Individuals