Ketogenic Diet in Healthy Adults With Differing BMI

Inclusion Criteria

• •1. Age 25-45 years
• •2. Fasting direct LDL-C ≤100 mg/dL
• •3. BMI of 18.5-22 kg/m2 or 30-35 kg/m2
• •4. Blood pressure \<140/90 mmHg
• •5. Fasting blood glucose \<126 mg/dL
• •6. Fasting triglycerides \<350 mg/dL
• •7. ≤10% change in body weight for 6 months prior to enrollment
• •14. Participation in another clinical trial within 30 days of baseline
• •15. Currently following a restricted or weight loss diet
• •16. Previously consumed the ketogenic diet for more than 1 week
• •17. Prior bariatric surgery
• •18. Intake of \>14 alcoholic drinks/week and/or lack of willingness to consume no alcohol while enrolled in the study and/or not willing to avoid alcohol consumption for 48 hours prior to test visits
• •19. Current or past eating disorder
• •20. Principal Investigator discretion related to the potential participant's ability to adhere to the study requirements including being able to come to the metabolic kitchen to pick-up food five days per week
• •21. Planning to relocate out of the State College area in the next 2 months
• •22. Unwilling to refrain from plasma/blood donations during the study
• •23. Previously diagnosed familial hypercholesterolemia
• •24. If a potential participant takes thyroid medicine, abnormal thyroid stimulating hormone (TSH) concentration (TSH outside of normal range of 0.5 - 4.5 mIU/L)