A Study to See if Lepodisiran Can Reduce Plaque in Coronary Arteries of Adults With Elevated Lp(a) Who Have Had Heart Events or Are at High Risk

Exclusion Criteria

• •Have had a major CV event less than 60 days before measurement of the Lp(a) level used for eligibility or uncontrolled high blood pressure at screening
• •Have moderate to severe renal dysfunction
• •Have severe heart failure
• •Have a history of coronary artery bypass graft surgery (CABG)
• •Have a planned coronary angiography, percutaneous coronary intervention (PCI), coronary artery bypass graft, or valvular intervention
• •Have had a procedure to remove lipoproteins from the blood or received therapy specifically targeting Lp(a)
• •Are unable to safely undergo CCTA due to medication intolerance, contrast allergies, or anatomical/technical factors