Effects of DL-3-n-butylphthalide on Chemotherapy-Induced Cognitive Impairment

Exclusion Criteria

• •1. Diagnosed with a cognitively impaired disease, such as Alzheimer's disease;
• •2. Patients will be excluded from fMRI testing if they are claustrophobic, have MRI contraindications such as pacemakers or metal implants, and patients who did not undergo fMRI testing may still participate in clinical trials if all other enrollment criteria are met;
• •3. Take medications that may affect cognitive function
• •4. History of brain metastases or other brain tumors;
• •5. History of stroke or severe head trauma;
• •6. History of epilepsy or other seizures;
• •7. Pregnant or considering becoming pregnant;
• •8. Any active nervous system or untreated/unremitted mental disorder (such as active major depressive disorder or other major mental disorder described in the DSM-5, allowing treatment of depression if treatment is stable)
• •9. Any history of alcohol or drug abuse or dependence within the past 2 years;
• •10. Any major systemic disease or unstable medical condition that may cause difficulty in complying with the protocol, including: a history of myocardial infarction or instability in the past year, serious cardiovascular disease (including angina or congestive heart failure with resting symptoms, or clinically significant abnormalities in the electrocardiogram), clinically significant and/or unstable lung, gastrointestinal, liver or kidney disease;
• •11. Have taken any non-research drugs to improve cognitive function within 4 weeks prior to enrollment;
• •12. Have taken butylphthalein in the past 30 days.