Taiwan Interstitial Lung Disease Multi-center Investigation and Registry

The goal of this prospective observational registry is to evaluate the long-term outcomes of patients diagnosed with fibrotic interstitial lung disease in Taiwan. The investigators will conduct a prospective registry and collect clinical data of fibrotic lung disease patients from multiple centers in Taiwan. The data collected will include basic epidemiological information, comorbidities, questionnaire results, routine blood tests, biochemical tests, pulmonary function tests, echocardiograms, and cardiopulmonary exercise tests (CPET). Each hospital will follow the same protocol for data collection, establishing a real-world Taiwan Fibrotic Lung Disease Registry Database. The details of this registry plan include: 1. Annual high-resolution computed tomography (HRCT) scans 2. Annual cardiopulmonary exercise tests (CPET) 3. Peripheral blood sampling for inclusion in a biobank 4. Additionally, echocardiograms and pulmonary function tests will be conducted every six months. The main questions it aims to answer are: 1. Is there a difference in all-cause mortality among ILD patients of different etiologies? 2. Is there a difference in the annual risk of acute exacerbation among ILD patients of different etiologies? 3. Evaluate the real-world data on the effectiveness of current anti-fibrotic drugs in treating idiopathic pulmonary fibrosis (IPF) and ILD of different etiologies. 4. Investigate the predictive ability of high-resolution computed tomography (HRCT) imaging features for mortality risk in ILD patients. 5. Explore the impact of comorbidities on the mortality risk of ILD patients. 6. Assess the predictive ability of biomarkers for disease progression and mortality.