Advanced Imaging to Assess the Effect of Immunosuppression on Progressive Fibrosis

Exclusion Criteria

• •1. Current or prior exposure to FDA approved anti-fibrotic therapy.
• •2. Extent of emphysema greater than extent of fibrosis.
• •3. Pregnancy or plans to become pregnant at baseline or during follow-up.
• •4. Contraindications to MRI.
• •5. Contraindications to receiving gadolinium-based contrast agents.
• •6. Research-related radiation exposure exceeds 50 millisievert (mSv) in the prior year.
• •7. Estimated glomerular filtration rate (eGFR) \< 30 mL/min (only for individuals with a history of chronic kidney disease).
• •8. Clinically significant pulmonary hypertension (PH) defined by use of pulmonary vasodilatory therapy.
• •9. Respiratory infection within the prior 6 weeks.
• •10. Smoking of any kind within the prior 6 months.