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Role of Aging and Individual Variation in Exercise Training Responsiveness | Clinical Trials | Clareo Health

RECRUITINGNA

Role of Aging and Individual Variation in Exercise Training Responsiveness

The Role of Aging and Individual Variation in Exercise Training Responsiveness

NCT06471569•Duke University

Summary

The primary purpose of this study is to assess the effects of aging on markers of physical reserve and exercise-induced adaptations in resilience in older adults who completed a structured exercise program within the last 15 years (Parent trial: STRRIDE-PD; NCT00962962). This feasibility pilot study will enroll up to 26 participants to complete a 6-month aerobic exercise intervention.

Eligibility

Age

60 - 90 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Individuals who completed participation in the STRRIDE-PD trial (NCT00962962)
•Body Mass Index (BMI) \> 18 and \< 45 kg/m2
•Stable dose (≥1 month) of any cardiometabolic medications

Exclusion Criteria

•Poor vein access
•Current use of tobacco or any nicotine products, including e-cigarettes
•Insulin-dependent diabetes
•Active untreated hypothyroidism with thyroid stimulating hormone (TSH) concentrations \> 10.0 uIU/mL
•Systemic inflammatory or connective tissue disease, chronic infectious disease, chronic pulmonary disease or symptomatic cardiovascular disease with positive functional study by ECG or imaging
•Current, actively treated malignancy other than dermatologic conditions
•Absolute contraindications to exercise testing: ongoing unstable angina; uncontrolled cardiac arrhythmia with hemodynamic compromise; active endocarditis; symptomatic severe aortic stenosis; decompensated heart failure; acute pulmonary embolism, pulmonary infarction, or deep vein thrombosis; acute myocarditis or pericarditis; acute aortic dissection; physical disability that precludes safe and adequate testing
•Relative contraindications to exercise testing: known obstructive left main coronary artery stenosis; moderate to severe aortic stenosis with uncertain relation to symptoms; tachyarrhythmias with uncontrolled ventricular rates; acquired advanced or complete heart block; hypertrophic obstructive cardiomyopathy with severe resting gradient; recent stroke or transient ischemic attack; mental impairment with limited ability to cooperate; uncorrected medical conditions, such as hypertension, significant anemia, important electrolyte imbalance, and hyperthyroidism
•Modified testing contraindications: acute myocardial infarction (MI) within six months; resting hypertension with systolic or diastolic blood pressures \>160/90 mmHg
•Unable to safely participate in an exercise program per study protocol per PI discretion
+1 more criteria

Locations (1)

Duke Center for Living

Durham, North Carolina, United States

Key Dates

Start Date

April 2, 2025

Primary Completion Date

March 31, 2027

Completion Date

March 31, 2027

Last Updated

November 14, 2025

Enrollment

ESTIMATED participants

Conditions

Prediabetic StateCardiovascular DiseasesInsulin ResistanceObesity

Interventions

Low/Mod

BEHAVIORAL

High/Mod

BEHAVIORAL

High/Vig

BEHAVIORAL

Contacts

Johanna L Johnson, MS

CONTACT

9196606766 johanna.johnson@duke.edu

Leanna M Ross, PhD

CONTACT

9196606688 leanna.ross@duke.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: November 14, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Role of Aging and Individual Variation in Exercise Training Responsiveness

Inclusion Criteria

Exclusion Criteria

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