To Investigate the Effect of Esketamine Hydrochloride on Pulmonary Complications

Exclusion Criteria

• •Non-cardiac surgery.
• •Second heart surgery.
• •Interventional surgery in heart valve surgery (TAVI, mitral clamp).
• •The patient refuses.
• •Pregnant women.
• •Patients with a history of lung surgery.
• •Patients with acute kidney injury requiring dialysis.
• •Patients with chronic renal insufficiency (stage III and above).
• •The patient was intubated before arriving at the operating room.
• •Patients with existing pulmonary complications (respiratory tract infection, pneumonia, pleural effusion, respiratory failure, atelectasis, pneumothorax, bronchospasm, ARDS).
• •The patient had neuropsychiatric disease and cognitive impairment before surgery.
• •Drug users and other long-term use of antipsychotic drugs.
• •Patients with any of the following contraindications for the use of ESketamine injection: patients with serious risk of elevated blood pressure or intracranial pressure; Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic pressure exceeding 180 mmHg, or resting diastolic pressure exceeding 100mmHg); Patients with untreated or undertreated hyperthyroidism (hyperthyroidism).
• •Liver function ALT, AST \> 2 times normal.