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Pathways Mediating Impaired Postural Control in Parkinson's Disease | Clinical Trials | Clareo Health

RECRUITING

Pathways Mediating Impaired Postural Control in Parkinson's Disease

NCT06464029•University of Minnesota

Summary

The purpose of this project is to use transcranial magnetic stimulation (TMS) to explore the state of excitability of corticocortical and corticofugal (cortex to spinal cord, cortex to brainstem to spinal cord) pathways that project to muscles that control the legs and trunk in people with Parkinson's disease. The outcome variables will be further analyzed to understand their relationship to quantitative measures of postural instability and gait dysfunction. As such, the project can be classified as basic physiologic research. The protocol is not designed to determine if measures of corticocortical or corticofugal excitability can be used as a biomarker to predict disease progression.

Eligibility

Age

45 - 80 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Participants with Parkinson's disease
•Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria.
•Age 45-80 years.
•Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters.
•Healthy Older Adults (Control participants)
•Age 45-80 years (this group will be age and sex-matched to the PD group)
•Able to ambulate independently without the use of an assistive device (cane or walker)
•Healthy Young Adults
•Age 21-44 years (this group will be age and sex-matched to the PD group)
•Able to ambulate independently without the use of an assistive device (cane or walker)

Exclusion Criteria

•Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers.
•Subjects who are on anti-coagulant medications.
•Any musculoskeletal disorder that affects the ability to stand.
•History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury.
•Intracranial metallic or magnetic devices.
•Pacemaker or any implanted device.
•History of surgery on blood vessels, brain or heart.
•Unexplained, recurring headaches or concussion within the last six months.
•Moderate to severe hearing impairment.
•Subjects who are pregnant.
+3 more criteria

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Key Dates

Start Date

June 1, 2024

Primary Completion Date

June 10, 2027

Completion Date

June 10, 2027

Last Updated

May 8, 2025

Enrollment

120

ESTIMATED participants

Conditions

Parkinson Disease

Contacts

Joshua De Kam

CONTACT

612-626-8052 jadekam@umn.edu

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 8, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Pathways Mediating Impaired Postural Control in Parkinson's Disease

Inclusion Criteria

Exclusion Criteria

[18F]F-DOPA Imaging in Patients With Autonomic Failure

Characterizing the Pathophysiological Role of the Pallido-thalamocortical Motor Pathway in Parkinson's Disease.

Montelukast in Parkinson Disease

Exercise for Cognitive Excellence in Parkinson's Disease

The Effect of Functional Rotational Exercises on Fall Risk and Mobility in Parkinson's Disease Patients

SAD Study in Patients With Parkinson's Disease and Motor Fluctuations