Fractional Flow Reserve-guided Stenting Versus Medical Therapy in Atherosclerosis Renal Artery Stenosis

Exclusion Criteria

• •SBP ≥200mmHg and/or DBP ≥120mmHg at the day or randomization;
• •Fibromuscular dysplasia or other non-atherosclerotic renal artery stenosis;
• •Pregnancy or unknown pregnancy status in female of childbearing potential;
• •Participation in any drug or device trial during the study period;
• •Any stroke/TIA, OR with ≥70% stenosis of carotid artery;
• •Any major surgery, myocardial infarction or interventional therapy 30 days prior to study entry;
• •LVEF \<30%;
• •Comorbidity condition causing life expectancy ≤1 year;
• •Allergy to contrast or any of the following: aspirin, clopidogrel;
• •Previous kidney transplant;
• •Previous renal artery bypass surgery or stent intervention;
• •Kidney size less than 8 cm measured by ultrasound;
• •Local lab serum Cr \>3.0 mg/dl (265.2μmol/l) on the day of randomization;
• •Reference vessel size \<4 mm or \>8 mm.