Lead Sponsor

Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Yes

•≥ 18 years
•(re-)active perianal fistula
•High perianal fistula tract (intersphincteric, transsphincteric, suprasphincteric) located in the upper two-thirds of the external sphincter or puborectal muscle
•Fistula with one internal opening (based on MRI imaging). The number of external fistulas does not have to be taken into account
•Written informed consent

•Proctitis (defined as any active mucosal inflammation or ulcer \> 5mm in the rectum)
•Anorectal stenosis (defined as the impossibility to introduce a proctoscope)
•Submucosal fistulas \& low intersphincteric fistulas (lower one-third of external sphincter)
•Rectovaginal fistula
•Multiple internal openings
•Use of Anti-TNF medication for more than 3 months
•Previous failure of Anti-TNF treatment for perianal fistula
•Patients with a stoma
•Dementia or altered mental status that would prohibit the understanding and giving of informed consent