The Effect of Omega 3 Supplementation on Postoperative Delirium in Elderly Patients Undergoing Major Cardiac Surgery

Exclusion Criteria

• •Inability to obtain written informed consent.
• •Inability to take study drug due to intubation or other reason.
• •Delirium present at screening.
• •Known hypersensitivity (e.g. anaphylactic reaction) to omega-3 ethyl esters or any of its components
• •Allergy to fish or shellfish
• •Currently taking warfarin (Coumadin), apixaban (Eliquis), dabigatran (Pradaxa), edoxaban (Savaysa/Lixiana), rivaroxaban (Xarelto), or other anticoagulant drugs.
• •Currently taking omega-3, omega-6, vitamin E, or fish oil supplements.
• •Significant renal disease with a serum creatinine ≥ 2 mg/dL.
• •Significant liver disease with alanine aminotransferase (ALT) levels 1.5 times the normal range of 6-45 units/liter and aspartate transferase (AST) levels 1.5 times the normal range of 10-42 units/liter.
• •History or diagnosis of diabetes.
• •History or diagnosis of neurodegenerative disease such as Parkinson's, Alzheimer's, or dementia.
• •History or diagnosis of bleeding disorder.
• •History or diagnosis of metabolic syndrome or disorder.
• •History or diagnosis of thyroid problems such as hyperthyroidism or hypothyroidism.