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Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision | Clinical Trials | Clareo Health

RECRUITING

Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision

Effect of Preoperative Inflammatory Biomarkers on Postoperative Delirium in Children Undergoing Circumcision

NCT07323485•Ankara Etlik City Hospital

Summary

Postoperative delirium may occur in children after general anesthesia, even following short procedures such as circumcision. Preoperative systemic inflammation has been associated with postoperative delirium in adults, but data in pediatric patients are limited. This prospective observational study aims to evaluate the association between preoperative inflammatory biomarkers and postoperative delirium in children aged 2-12 years undergoing elective circumcision under general anesthesia. Inflammatory biomarkers derived from routine complete blood count parameters, including NLR, PLR, MLR, SII, and SIRI, will be analyzed. Postoperative delirium will be assessed using the Pediatric Anesthesia Emergence Delirium (PAED) scale in the post-anesthesia care unit. The relationship between inflammatory biomarkers and delirium development and severity will be evaluated. This study seeks to identify simple preoperative markers that may help predict postoperative delirium risk in pediatric patients.

Eligibility

Age

2 - 12 years

Sex

MALE

Healthy Volunteers

Yes

Inclusion Criteria

•Children aged 2-12 years.
•Patients scheduled to undergo elective circumcision under general anesthesia.
•Patients classified as ASA physical status I-II.
•Patients whose parents or legal guardians provide written informed consent, and whose age-appropriate verbal assent is obtained from the child.
•Patients in whom anesthesia and surgical procedures are performed according to standard institutional protocols throughout the study period.

Exclusion Criteria

•Children with a history of neurological or psychiatric disorders (e.g., epilepsy, developmental delay, autism spectrum disorder, anxiety disorders).
•Patients classified as ASA physical status III-IV.
•Patients with incomplete preoperative laboratory data or with hematological or hormonal disorders that may affect inflammatory parameters.
•Patients who develop excessive sedation after premedication or whose preoperative assessment cannot be completed.
•Patients with protocol deviations during surgery or anesthesia (e.g., additional medications, prolonged surgical duration, or changes in procedure due to complications).
•Patients whose parents or legal guardians do not provide consent or who decline participation.

Locations (1)

Ankara Etlik City Hospital

Altındağ, Ankara, Turkey (Türkiye)

Key Dates

Start Date

January 18, 2026

Primary Completion Date

June 10, 2026

Completion Date

July 25, 2026

Last Updated

February 20, 2026

Enrollment

140

ESTIMATED participants

Conditions

Postoperative DeliriumPediatric AnesthesiaInflammatory Biomarkers

Interventions

Measurement of Preoperative Inflammatory Biomarkers

OTHER

Contacts

Ahmet Murat Gül

CONTACT

00905071399560 dr_gag@hotmail.com

Aslı Dönmez

CONTACT

00905322256473 aslidonmez@hotmail.com

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 20, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Inflammatory Biomarkers and Postoperative Delirium in Pediatric Circumcision

Inclusion Criteria

Exclusion Criteria

Naples Prognostic Score for Predicting Postoperative Delirium

Intraoperative Infusion of Either Lidocaine or Dexmedetomidine on Regional Cerebral Oxygen Saturation and Postoperative Delirium in Elderly Patients Undergoing Abdominal Surgeries

The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium

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