Efficacy of Targeted Medical Therapy in Angina and Nonobstructive Coronary Arteries

Inclusion Criteria

• •All patients with stable angina referred to the Stanford University Hospital cardiac catheterization laboratory for clinically indicated coronary function testing are eligible for inclusion into the study.
• •Absence of significant epicardial coronary artery disease on angiography
• •Fractional flow reserve \> 0.80
• •And ≥ 1 of the following:
• •Epicardial coronary spasm on acetylcholine testing
• •Microvascular spasm on acetylcholine testing
• •Coronary flow reserve \< 2.5
• •Index of microcirculatory resistance ≥ 25
• •Myocardial bridge on intravascular ultrasound with dobutamine resting full-cycle ratio ≤ 0.76